The disposable tip in a positive displacement micropipette is a microsyringe composed of a capillary and a piston (movable inner part) which directly displaces the liquid. In these pipettes, the piston comes in direct contact of the sample. Instead, a disposable micropipette tip is used to draw the liquid into and dispense from the pipette. The internal mechanism of the pipette does not come in direct contact of the sample/liquid. It consists of a piston that aspirates and dispenses liquid samples as the air pocket moves up and down, respectively. This type of micropipette works on the air displacement principle. Micropipettes can be classified depending upon: A pipette with a universal tip cone is preferred as it enhances the compatibility of the instrument with most of the standard tips. The tip cone provides fitment to the tips. This shows the volume of the liquid to be aspirated or dispensed. The tips can be easily removed from the micropipette by pressing the tip ejector button. So in order to allow the safe, effortless and quick ejection of tips, micropipettes are provided with a tip ejection system. Instead, a disposable micropipette tip is used to draw the liquid into and dispense from the micropipette. The internal mechanism of the micropipette does not come in direct contact of the sample/liquid. Press and depress the plunger to aspirate or dispense liquid. A distinct click sound at every volume change ensures perfect volume setting and prevents any accidental volume change.

Rotate the plunger clockwise/ anticlockwise to decrease/ increase the volume setting. The plunger performs the following two functions. Certain micropipettes are provided with a calibration tool and a micropipette stand as an accessory. These include the plunger, digital display, tip cone, tip ejector and grippy.

However, there are certain components that are basic and common to all micropipettes. Micropipettes are available in different designs and sizes. While the single-channel micropipettes are used in labs that perform research related to molecular biology, microbiology, immunology, cell culture, analytical chemistry, biochemistry and genetics, the multichannel micropipettes are recommended for ELISA (diagnostic test), molecular screening, kinetic studies and DNA amplification. Micropipettes are available in single-channel and multi-channel variants. A micropipette is a common yet essential laboratory instrument used to accurately and precisely transfer volumes of liquid in the microliter range.

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